ABSTRACT - ADMINISTRATION The O’Neal Comprehensive Cancer Center (O’Neal) Administration functions as the central hub for all O’Neal activities and initiatives within the matrix academic medical center environment of the University of Alabama at Birmingham (UAB). The focus of Administration is the effective facilitation and operational delivery on the mission and vision of the Center to benefit O’Neal members’ research endeavors, our patients through access to novel interventions delivered by interdisciplinary specialists, training of the next generation of cancer research professionals, and implementation of our knowledge for the betterment of the citizens of Alabama, the O’Neal catchment area. Administration is central to the functioning of O’Neal and is engaged in all aspects of strategic planning with Senior Leadership as well as implementation of daily operations of one of the original NCI designated cancer centers with a history dating back to 1971. Administration is included in all decision making as well as resource allocation activities of O’Neal providing support for evidenced based decisions and planning. The Administration is organized to provide coordinated and efficient services that are not otherwise available to O’Neal members at UAB with an overarching goal to underpin the success of the O’Neal strategic plan. The Administration consists of 115 dedicated and experienced staff focused on delivering the strategic mission of the O’Neal. In the current funding period, the Administration has provided stability and operational integrity during two O’Neal Director leadership transitions and led the effort that culminated in a transformative naming gift of $30M from the O’Neal family and O’Neal Industries. Administration facilitated the recruitment of 54 new O’Neal members to UAB. The recruitment effort represents a total of $13.2M in O’Neal resources invested in new members of our research community. Administration managed 33 CCSG supplement applications with 17 successful administrative supplements to the CCSG totaling $5.4M in direct cost support to our mission and supported the submission and acquisition of two NCI P01s, one in cancer prevention and another in cancer survivorship. Administration acquired and implemented the EVAL center management software system, providing better Center analytics driving data-informed decisions. In collaboration with the Director and Senior Leaders, Administration guided the O’Neal through the evaluation and consolidation from six research programs down to four by providing CCSG guideline expertise, program relevant data, modeling programmatic changes and additional decision support analytics. In summary, the Administration functions as an integral component of the O’Neal to deliver our vision, Life without cancer.