Abstract The All of Us Research Program (AoU) has created a national research dataset unprecedented in size, diversity, and scope to advance precision medicine. However, data utilization is not yet commensurate with the power and potential impact, and researchers utilizing the dataset are not yet representative of communities historically underrepresented in biomedical research (UBR). The AoU's innovative cloud-based, centralized data governance requires broad professional development training for researchers, with a focus on informatics literacy and technical resources to support analysis within the AoU Researcher Workbench (AoURW). The University of Arizona (UArizona)-Banner AoU team will address this challenge through four Aims derived from our extensive experience leading interdisciplinary scientific teams to utilize AoURW and creating programs to engage researchers from UBR communities. Aim 1: Establish an AoU Data Fellows program to train and mentor researchers from UBR communities in leveraging the AoURW. Data Fellows will subsequently engage in outreach within their own networks to encourage AoUfocused research projects and awareness. Aim 2: Advance and manage a biomedical informatics core dedicated to equipping UBR and nontraditional researchers to conduct research in the AoURW. Aim 3: Incentivize AoURW research through high priority driver projects and seed grants with a focus on UBR and early-career investigators and health equity research. Aim 4: Form an Advisory Council (AC) to oversee Aims 1-3 and create partnerships with scientific organizations to engage researchers and scale initiatives nationally. Aims 1-4 will cultivate an active, diverse, and sustainable pool of AoU-focused researchers empowered by our resources and AoURW’s directive to advance precision medicine for the benefit of all communities. We will engage researchers from UBR communities to utilize the AoURW using active engagement strategies based on the principles of community based participatory research and research capacity building, while maintaining the flexibility to work with existing AoU partners and extend AoU resources. Our UArizona-Banner AoU team will assess the impact of our activities, disseminate promising practices to the broader scientific community, evaluate our initiatives against AoU programmatic objectives, and ensure that our researchers’ perspectives inform AoURW development—driving AoU further toward an inclusive ecosystem and an equitable platform.