Project Summary The Icahn School of Medicine at Mount Sinai proposes to continue a highly successful Training Program in Cancer Biology for 5 predoctoral students and 5 postdoctoral fellows. The planned duration is up to 2 years for each predoctoral slot and up to 3 years for each postdoctoral slot. The projected number of individuals to be trained over the proposed project period is 15 predoctoral and 10 postdoctoral fellows. Its leadership has extensive experience in cancer research mentoring and a well-documented commitment to both graduate education and postdoctoral training. This institutional program encompasses training faculty from 6 basic and 4 clinical departments as well as 12 matrix institutes and involves laboratory and computational research. The dynamic and interdisciplinary nature of the Program is evidenced by co- authored papers and multi-investigator grants. All faculty members have peer-reviewed R01 or R01-equivalent support from funding agencies for cancer-related studies. The Program attracts and develops a cadre of outstanding Ph.D. and M.D., Ph.D. students, and postdoctoral fellows, with our earliest trainees having established cancer-focused research careers at prestigious institutions. The curriculum for predoctoral and postdoctoral trainees involves common elements including several new advanced didactic and multi-modal cancer biology courses and advanced electives, which impart state-of-the-art training in emerging technologies critical to basic and translational cancer investigations. All trainees also participate in regular conferences, which further expose them to clinical aspects of cancer. There are important specific training elements for each component as well. There is a rigorous evaluation and selection process, and the program is both cognizant of and actively involved in diversity recruitment. New components of the program also include additional training venues to specifically aid postdoctoral trainees in seeking academic positions and a formal training faculty track in which promising junior faculty members may apply with a training faculty member to co-mentor a highly qualified trainee, an approach providing mentorship by the training faculty member both of the trainee and the faculty co-mentor. The program has contributed importantly to the remarkable increase in cancer research and NCI funding over the past decade. Mount Sinai has also made enormous commitments in resources and facilities benefitting the Program including support for specific elements by the Tisch Cancer Institute an NCI designated Cancer Center and the Department of Oncological Sciences. Trainees work closely with faculty drawn from throughout Mount Sinai ensuring that their training is both rigorous and sufficiently broad in scope to take into account practical issues faced by physicians in preventing and treating cancer.

Project Narrative Cancer biology research within this institutional, multidisciplinary training program is aimed at elucidating the molecular mechanisms responsible for initiation and progression of human cancer. Translational research is also directed at improving diagnosis and therapies for this terrible disease, and our training faculty have made discoveries that have led to new cancer therapies. Both pre- and postdoctoral trainees participate in rigorous didactic as well as state-of-the-art laboratory and/or computational research training with the earliest cadre having now established academic careers in cancer research.