DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishments and the use of the first person. This abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. The Rochester Clinical Research Curriculum (RCRC) has developed a comprehensive program to provide clinical research trainees with the knowledge, methods, and skills to be successful clinical investigators. The overall goal of this proposed program is to further refine and expand the core competencies and educational objectives for clinical research training. The RCRC will build upon an excellent established curriculum of didactic coursework, a program of skill-building workshops to provide practical tools for contemporary clinical research, a Clinical Research Seminar Series, and mentored research experiences. The RCRC has successfully recruited 89 Scholars who have already shown considerable research productivity. On this solid foundation, clinical research at the University of Rochester has been reorganized and expanded. Five multidisciplinary research tracks (translational research; experimental therapeutics; population-based research; outcomes research; and ethics, law and policy) have been developed. Two new skill-building workshops are proposed: Recruitment and Retention of Research Subjects, and Research Program Administration. Three workshops (Ethical Conduct of Research, Grant Writing and Research Project Administration) will be provided online for sharing with clinical research partners. A Clinical Research Resource Inventory will be kept current for trainees to identify mentors and research resources. The mentored research experience will be improved by an online Mentor Development Course to improve the quality and quantity of clinical research mentors. Recruitment of Scholars will be expanded with collaboration with regional and national partners. The RCRC will simultaneously be evaluated for completion of learning objections, productivity of trainees during the training period and thereafter, and RCRC Scholars' career development. With these improvements the RCRC should be even more successful in training RCRC Scholars for successful careers in clinical research. PERFORMANCE SITE(S) (organization, city, state) University or Rochester School of Medicine and Dentistry, Rochester, New York University of Rochester School of Nursing, Rochester, New York Eastman Dental Center, Rochester, New York University of Rochester Medical Center, Rochester, New York KEY PERSONNEL. See instructions. Start with Principal Investigator. List Name See Attached Disclosure Permission Statement. PHS 398 (Rev. 05/01) Use continuation pages as needed to provide the required information in the format shown below. all other key personnel in alphabetical order, last name first. Organization Role on Project Applicable to SBIR/STTR Only. See instructions. [] Yes [] No Page 2 Number pages consecutively at the the application. Do not use suffixes bottom throughout Form Page 2 such as 2a, 2b. Name Thomas Pearson, MD, MPH, PhD June Arkoulis-Sinclair Diane Becker, RN, ScD Carla Boff Patricia Braus, MPH Gary Chadwick, PhD Nancy Chin, PhD Mark Cobum, MS Andrew Dick, PhD Will DiGrazio Ann Dozier, RN, PhD Timothy Dye, PhD C. McCollister Evarts, MD Howard Federoff, MD, PhD Diana Fernandez, MD, PhD Susan Fisher, RN, PhD Thomas Fogg, MPP John Gerich, MD Donna Giles, PhD Yana Grady-Weliky, MD Sandra Griffin-Roth Joseph Guido, MS David Guzick, MD, PhD Robert Haggerty, MD Kathleen Hoeger, MD Robert Holloway, MD, MPH Karl Kieburtz, MD, MPH Pattie Kolomic Kerry Knox, PhD Norman LaFrance, MD Jill Lavigne, PhD Gunta Liders Michael McDermott, PhD Bernadette Melnyk, RN, PhD Cyril Meyerowitz, DDS Ekaterina Noyes, PhD, MPH Elizabeth Ofili, MD Deborah Ossip-Klein, PhD Gary Paige, MD Richard Reichman, MD Christopher Ritchlin, MD Michael Ritz Jason Roy, PhD Stanley Schaffer, MD, MPH Julie Sollenberger Dwight Stapleton, MD Peter Szilagyi, MD, MPH James Tacci, MD, MPH, JD Mark Taubman, MD Helena Tempkin-Greener, PhD Sally Thurston, PhD Russell Tracy, PhD Sarah Traflon, JD Michael Weitzman, MD Janet Williams, MD Elizabeth Woodard, MD, MPH Key Personnel Organization Professor and Chair, Department of Community and Preventive Medicine, Sr. Associate Dean for Clinical Research, SOM Department of Community and Preventive Medicine Professor of Medicine, Johns Hopkins University Department of Community and Preventive Medicine Department of Community and Preventive Medicine Director, Office of Human Subjects Protection Department of Community and Preventive Medicine Office of Technology Transfer, U of R Department of Community and Preventive Medicine GCRC, SOM Department of Community and Preventive Medicine Department of Community and Preventive Medicine Sr. Vice President for Health Affairs Sr. Associate Dean for Basic Research Department of Community and Preventive Medicine Department of Community and Preventive Medicine Office of Clinical Research, SOM Director, GCRC, Department of Medicine, SOM Department of Psychiatry Sr. Associate Dean for Medical Education Department of Community and Preventive Medicine Department of Community and Preventive Medicine Dean, SOM Professor Emeritus, Pediatrics, SOM Department of Obstetrics/Gynecology Department of Neurology Department of Neurology Department of Community and Preventive Medicine Department of Community and Preventive Medicine Sr. Vice President, Celltech Americas, Inc. Department of Community and Preventive Medicine Director, Office of Research and Program Administration Biostatistics and Computational Biology Associate Dean for Research, SON Director, Eastman Dental Center; Chair, Dentistry Department of Community and Preventive Medicine Professor and Director of CRC, Morehouse SOM Department of Community and Preventive Medicine Department of Anatomy and Neuroscience Department of Medicine Department of Medicine Office of Special Project Accounting Department of Biostatistics Department of Pediatrics Director, Miner Library, SOM Director of Clinical Research, Guthrie Health System Department of Pediatrics Department of Community and Preventive Medicine Department of Medicine Department of Community and Preventive Medicine Department of Biostatistics Sr. Associate Dean for Research, University of VT Associate Chair, Department of Community and Preventive Medicine Department of Pediatrics Department of Emergency Medicine Department of Community and Preventive Medicine Role in Project Program Director; Chair, Mentoring Committee Workshop Faculty External Advisory Board Evaluation Committee Workshop Faculty Seminar Committee Course Faculty Workshop Faculty Curriculum Committee Workshop Faculty Chair, Evaluation Committee, Executive Committee Curriculum Committee, Workshop Faculty Chair, External Advisory Board Multidisciplinary Advisory Committee Course Faculty Multidisciplinary Advisory Committee, Course Faculty, Curriculum Committee Program Administrator Multidisciplinary Advisory Committee Mentoring Committee Co-Chair, Admission Committee, Executive Committee Seminar Coordinator Course Faculty Chair, Multidisciplinary Advisory Committee External Advisor'/Board Multidisciplinary Advisory Committee Multidisciplinary Advisory Committee, Course Faculty Multidisciplinary Advisory Committee Graduate Advisor Course Faculty External Advisory Board Course Faculty Workshop Faculty Course Faculty Multidisciplinary Advisory Committee Multidisciplinary Advisory Committee Course Faculty External Advisory Board Curriculum Committee, Course Faculty Multidisciplinary Advisory Committee Multidisciplinary Advisory Committee Multidisciplinary Advisory Committee Workshop Faculty Course Faculty Course Faculty Workshop Faculty Extemal Advisory Board Mentoring Committee Course Faculty Multidisciplinary Advisory Committee Course Faculty Course Faculty External Advisory Board Chair, Curriculum Committee; Program Associate Director Multidisciplinary Advisor}, Committee Multidisciplinary Advisory Committee Course Faculty Principal Investigator/Program Director (Last, First, Middle): Pearson, Thomas A. The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT