Washington University Paul Calabresi K12 Career Development Award for Clinical Oncology Project Summary / Abstract The goal of the Washington University (WU) Paul Calabresi K12 Career Development Award (K12 program) for Clinical Oncology is to provide didactic coursework, mentored research practicums and specialized career development programs for clinician scientists possessing an MD, DO, PharmD, nurses with PhDs, or equivalent degree. We propose the renewal of this K12 to continue training clinicians from diverse disciplines, including medical oncology, surgical oncology, gynecological oncology, radiation oncology and pediatric oncology to promote their career development as cancer researchers and to design and administer hypothesis-driven pilot/Phase I, Phase II, and Phase III cancer therapeutic clinical trials. We are requesting five slots per year to support eligible scholars for two to three-year appointments. To enhance our highly successful K12 program, we propose the following: Aim 1: Expand the workforce trained to design and execute rigorous oncologic clinical research. We propose to fund five K12 scholar positions per year at WU over the next five years to train eligible applicants from diverse disciplines focused on patient-oriented cancer research. Aim 2: Optimize existing curricula, career development, short-term training, and mentored, hands-on research experiences pertinent to clinical trials and patient oriented research. We expanded upon our opportunities to offer training in four tracks: Cancer Genomics, Translational Medicine, Patient Centered Outcomes Research, and Cancer Immunology and Cellular Therapy. Aim 3: Continue to develop and enhance robust evaluation and tracking of K12 scholars, faculty, mentors, curriculum, and training opportunities. We will monitor progress, demonstrate outcomes, and use short- and long-term results to improve clinical oncology research training. Successful completion of these aims will result in increased numbers of diverse, well-trained investigators who lead hypothesis driven cancer clinical trials. By partnering with stakeholders early and throughout the translational enterprise, they will disseminate and implement their research findings in real world practice to advance rapid human health and health care improvements.

Washington University Paul Calabresi K12 Career Development Award for Clinical Oncology Project Narrative: Washington University Paul Calabresi Oncology K12 Program aims to train a new generation of clinicians in genetics/genomics, translational medicine, patient centered outcomes research, and cancer immunology and cellular therapy in order to improve the outcomes for cancer patients.