PROJECT SUMMARY/ABSTRACT We are requesting funds for The Paul Calabresi Career Development Award for Clinical Oncology in Pediatric and Medical Hematology/Oncology at the Fred Hutchinson Cancer Research Center, University of Washington School of Medicine and Seattle Children’s Hospital. The Career Development Program will interface with our Pediatric Hematology/Oncology, Medical Oncology, and adult Hematology Training Programs at the Fred Hutchinson Cancer Research Center and the Departments of Pediatrics and Medicine at the University of Washington, with the goal of developing and supporting transition of clinical translational investigators into independent investigators. This K12 Career Development Award for Clinical Oncology will be an integral part of our program towards grooming the next generation of independent clinical researchers by supporting four physicians each year who have completed fellowship training in the pediatric or medical hematology/oncology training programs with track record of promising independent clinical/translational careers. Prior to entry into the program, scholar candidates will have acquired clinical skills and basic laboratory tools of modern biology and translation of laboratory findings to clinical application. Those most qualified and motivated to enter into investigative endeavors in clinical translational research will be selected. The K12 scholars will receive two to three years of funding to help develop requisite experience to conduct clinical translational research, translate their findings to patients, and generate sufficient data to help establish independent research careers. The aim of their projects will be to contribute new and useful information relevant to clinical oncology and to develop the clinical research capabilities of the trainees. The supported research projects include those in the areas of hematopoietic stem cell transplantation, immunology and immunotherapy, transplantation biology, outcome and quality of life research, malignant hematopoiesis, human immunogenetics, and programs in solid tumor research including tumors of the brain, breast, ovaries, prostate, and breast. Additional projects in molecular biology and gene therapy, as well as other relevant research arenas, will be available. Trainees will also gain experience in clinical protocol development, conduct, and evaluation, and will receive didactic training in biostatistics, clinical trial design and biomedical research integrity. This program utilizes the laboratory and clinical research facilities of the Fred Hutchinson Cancer Research Center, the University of Washington, and the Seattle Children’s Hospital Research Institute, and the clinical facilities of the Seattle Cancer Care Alliance, The University of Washington, and the Seattle Children’s Hospital.

Project Narrative The aim of the Pediatric and Medical Oncology Career Development Program is to provide physicians with the tools and experience necessary to conduct clinical research, translate their findings to patients, and generate sufficient data to help establish independent research careers. Trainees will contribute new and useful information relevant to clinical oncology.