Total knee replacement (TKR) is commonly used to reduce pain and improve function in patients with
advanced, symptomatic knee osteoarthritis (OA). While more than 80% of patients undergoing TKR report
improved pain and functional status, growing evidence suggests that post-TKR physical activity (PA) does not
surpass pre-TKR levels. Given the substantial time and financial investment associated with TKR and the rich
evidence supporting health benefits of PA, the effectiveness and cost-effectiveness of TKR could be
meaningfully enhanced if TKR recipients would be more physically active. The period following acute TKR
rehabilitation provides a unique window of opportunity for these patients to transform their lifestyles. This
proposal addresses whether introducing behavioral strategies that incorporate both intrinsic and extrinsic
motivators can help TKR recipients engage in sustained, meaningful PA. Telephonic active coaching with
motivational interviewing (TAC(MI)) uses regular conversations to resolve ambivalence and identify means of
overcoming barriers to PA. Financial incentives (FI) address the temporal delay between completing healthy
behaviors and receiving long-term health benefits by offering immediate rewards contingent on activity and
performance. With these behavioral, psychological and economic principles in mind, we propose KArAT
(Knee Arthroplasty Activity Trial). The long-term objective of this research is to determine the most
effective and cost-effective behavioral interventions post-TKR to help patients develop a sustained
commitment to becoming physically active. We plan to conduct a three-arm parallel RCT to establish the
efficacy of personalized intervention built on the principles of behavioral science and behavioral economics in
improving PA among patients who have undergone TKR. The three arms will include: Arm 1: Usual Care (UC);
Arm 2: Attention Control (AC); Arm 3: Telephonic Active Coaching (Motivational Interviewing) + Financial
Incentives (TAC(MI)+FI). In general, RCTs focus on either treatment-specific effect or total treatment effect.
In this application, we propose a design that will permit us to estimate both. By including a ‘usual care’ arm, we
will be able to estimate the overall effect of the intervention, which is relevant to estimating the value of the
intervention and understanding the impact on clinical practice. The primary outcome will be the proportion of
individuals engaging in at least 150 minutes per week of moderate-to-vigorous physical activity (MVPA) at ≥3
METs by the end of the six-month intervention. Change in average daily step count from pre-TKR to the end of
the six-month intervention; change in weekly minutes of MVPA; reduction in sedentary time; and
sustainability of efficacy at 12, 18 and 24 months post-TKR will be secondary outcomes. The results from
KArAT will help clinicians, patients and policymakers make evidence-based decisions about improving PA after
TKR, one of the most common orthopedic surgeries.
Public Health Relevance Statement
Public Health Statement:
The 2018 Center for Disease Control and Prevention (CDC) guidelines recommend that all adults engage in at
least 150 minutes of physical activity weekly; however, uptake of PA is poor among patients who undergo total
knee replacement, despite substantial pain relief as a result of the surgery. We propose a randomized trial of a
multimodal behavioral intervention—telephonic health coaching and financial rewards—to encourage patients
with osteoarthritis who have undergone a total knee replacement surgery to become more physically active. If
the intervention proves effective and cost-effective, it could lead to a fundamental change in the strategy for
increasing physical activity in patients undergoing total knee replacements.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AcuteAddressAdoptedAdultAttitudeBehaviorBehavior TherapyBehavioralBehavioral SciencesBeliefCenters for Disease Control and Prevention (U.S.)ClinicalDegenerative polyarthritisEconomicsEffectivenessEnsureFatigueFutureGrantHealthHealth BenefitImplantIncidenceIndividualInternetInterventionInvestmentsKneeKnee OsteoarthritisLife StyleMeasuresMedicalMethodologyMindNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesObesityOperative Surgical ProceduresOrthopedic SurgeryOrthopedic Surgery proceduresPainPain managementPatientsPerformancePersonsPhysical activityPolicy MakerPopulationPrevention GuidelinesPublic HealthQuality of lifeRecommendationRehabilitation therapyReportingResearchRewardsTelephoneTestingTimeTreatment EfficacyWorkWorld Health Organizationarmattentional controlbehavior changebehavioral economicsclinical practicecomorbiditycostcost effectivecost effectivenesscritical perioddesigneconomic incentiveevidence baseexperiencefinancial incentivefitbitfunctional improvementfunctional statusgood dietimprovedinnovationintervention effectknee replacement arthroplastymoderate-to-vigorous physical activitymotivational enhancement therapymultidisciplinarymultimodalitypain catastrophizingpain reductionpain reliefpatient orientedpersonalized interventionpoor sleeppost interventionprimary outcomeprotocol developmentpsychologicpublic health prioritiesrandomized trialsecondary outcomesedentarysleep qualitytreatment as usualtreatment effecttv watchinguptakeusual care arm
National Institute of Arthritis and Musculoskeletal and Skin Diseases
CFDA Code
846
DUNS Number
030811269
UEI
QN6MS4VN7BD1
Project Start Date
23-September-2022
Project End Date
31-August-2027
Budget Start Date
01-September-2024
Budget End Date
31-August-2025
Project Funding Information for 2024
Total Funding
$717,317
Direct Costs
$736,100
Indirect Costs
$370,781
Year
Funding IC
FY Total Cost by IC
2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
$717,317
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5R01AR080346-03
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 5R01AR080346-03
Patents
No Patents information available for 5R01AR080346-03
Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 5R01AR080346-03
Clinical Studies
No Clinical Studies information available for 5R01AR080346-03
News and More
Related News Releases
No news release information available for 5R01AR080346-03
History
No Historical information available for 5R01AR080346-03
Similar Projects
No Similar Projects information available for 5R01AR080346-03