TB Clinical Research: Training the Next Generation
Project Number5K24AI001833-04
Contact PI/Project LeaderHAMILTON, CAROL D
Awardee OrganizationDUKE UNIVERSITY
Description
Abstract Text
DESCRIPTION (provided by applicant): The Investigator, Carol Dukes Hamilton, M.D., will use NIH K24 funding to help train future generations of clinical-scientists for a career in tuberculosis (TB) research. TB is responsible for more human deaths than any other infectious disease. Dr. Hamilton's long-term research goals are to optimize strategies for treating active and latent TB in adults and children. Strengths of her program include ongoing funding and active participation in the CDC-funded TB Trials Consortium clinical trials group, the CDC-funded TB Epidemiologic Studies Consortium, and an NHLBI-funded study of genetics of TB susceptibility. These funded programs form the basis of her research enterprise. They combine perfectly with the opportunities afforded by her position as the Medical Director for North Carolina's TB Control Program, providing an avenue for subject recruitment, clinical and epidemiologic research training for advisees, and the opportunity to implement changes based on the findings.
The strength of Dr. Hamilton's TB research program is that she employs both clinical trials and epidemiologic studies to attain her research goals. Trainees can tap into one or the other methodologies during their training. Didactic course work leading to either a Masters in Clinical Research Science or Public Health is an integral part of Dr. Hamilton's mentoring plan. Dr. Hamilton will also strengthen her experiencebased research capability using these resources. Dr. Hamilton's research plan includes a description of the TB Trials Consortium clinical trial, "Study 26", comparing the effectiveness of 9 months of daily isoniazid therapy to 12 doses of weekly isoniazid plus rifapentine, for treatment of latent TB infection. Planned and potential sub-studies and secondary analyses provide fertile substrate for trainee-initiated research projects. The research plan also includes her NHLBI funded genetic epidemiologic study of candidate genes that may contribute to human TB susceptibility. Her work with the Duke Center for Human Genetics is an example of translational research she hopes to foster within her mycobacteria research program.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AIDS clinical trial groupAcademiaAcademic Medical CentersAcademic TrainingAchievementAcquired Immunodeficiency SyndromeAddressAdoptedAdultAdvanced Practice NurseAdvisory CommitteesAdvocacyAdvocateAffectAfrica South of the SaharaAgreementAlabamaAlcoholismAlcoholsAlzheimer's DiseaseAmbulatory Care FacilitiesAmericanAmericasAnti-Retroviral AgentsAntibioticsAntitubercular AgentsAppendixApplaudApplications GrantsApplied ResearchAppointmentAreaAttentionAttitudeAutistic DisorderAwardBangladeshBasic ScienceBehaviorBehavioralBeliefBenchmarkingBenefits and RisksBioinformaticsBiologicalBiologyBiometryBioterrorismBirthBooksBotswanaBoxingBronchiectasisCanadaCandidate Disease GeneCardiologyCaregiversCaringCase-Control StudiesCell surfaceCellular TropismCenters for Disease Control and Prevention (U.S.)Cessation of lifeChairpersonCharacteristicsChestChildChildhoodChronicCitiesClassClinicClinicalClinical InvestigatorClinical ResearchClinical TrialsClinical Trials Cooperative GroupClinical Trials DesignClinical Trials-Pediatric AIDSCollaborationsCollectionCommitCommittee MembersCommunicable Disease ControlCommunicable DiseasesCommunitiesCompassionComplexComputer SystemsConcept ReviewConsensusConsultConsultationsConsumptionContractsCoordination and CollaborationCore FacilityCost-Benefit AnalysisCounselingCountryCountyCreativenessCutaneousDNADNA LibraryDailyDataData AnalysesData CollectionData SetDatabasesDaughterDepthDetectionDevelopmentDiagnosisDiagnosticDiagnostic testsDialysis patientsDialysis procedureDiarrheaDietitianDimensionsDiscipline of NursingDiscipline of obstetricsDiseaseDistrict of ColumbiaDoctor of MedicineDoctor of PharmacyDoctor of PhilosophyDoseDropsDrug InteractionsDrug KineticsDrug Rehabilitation CentersEconomic FactorsEconomicsEducationEducational ActivitiesEducational CurriculumEducational InterventionEducational StatusEducational process of instructingEducational workshopEffectivenessElectronic MailElementsEmployeeEmployee StrikesEnd PointEnrollmentEnsureEnvironmentEpidemicEpidemiologic StudiesEpidemiologistEpidemiologyEtiologyEvaluationEvaluation ResearchEventEvolutionExhibitsExpenditureExplosionFacultyFamilyFamily PracticeFamily StudyFeesFellowshipFinancial SupportFloridaFollow-Up StudiesFosteringFoundationsFriendsFrightFruitFundingFunding AgencyFutureFuture GenerationsGenerationsGenesGeneticGenomicsGenus MycobacteriumGoalsGovernment AgenciesGrantGroupingGrowthGuidelinesGynecologyHIVHIV InfectionsHIV-1HandHeadHealthHealth ProfessionalHealth SciencesHealth ServicesHealth Services ResearchHealth StatusHealthcareHearingHepatitis B VaccinesHigh PrevalenceHighly Active Antiretroviral TherapyHispanicsHospice CareHospital PlanningHospitalizationHospitalsHourHouse StaffsHumanHuman GeneticsHuman GenomeHuman ResourcesHuman immunodeficiency virus testHumorImmigrantImmunityImmunologyIncidenceIndiaIndiumIndividualIndustryInfectionInfection ControlInformation CentersInformation TechnologyInpatientsInstitutesInstitutionIntelligenceInterdisciplinary StudyInternal MedicineInternationalInternetInternship and ResidencyInternshipsInterventionInterviewInvestigationInvestmentsItraconazoleJointsJournalsK-Series Research Career ProgramsKnowledgeLaboratoriesLaboratory ResearchLaboratory StudyLeadLeadershipLearningLeftLettersLifeLinkLocationLungLung diseasesLymphocyteMailsManuscriptsMaster's DegreeMeasuresMedicalMedical MicrobiologyMedical StudentsMedical centerMedicineMelissaMentored Clinical Oncology AwardMentored Clinical Scientist AwardMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMetabolicMethodologyMethodsMicrobiologyMid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented ResearchMissionModalityModelingMolecularMolecular GeneticsMolecular WeightMonitorMonographMorbidity - disease rateMothersMulti-Drug ResistanceMulti-Institutional Clinical TrialMulticenter TrialsMultidrug-Resistant TuberculosisMycobacterium InfectionsMycobacterium avium ComplexMycobacterium tuberculosisMycosesNCI Scholars ProgramNamesNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseaseNatureNeopterinNew HampshireNorth CarolinaNotificationNucleic Acid Amplification TestsNucleic AcidsNucleosidesNumbersNurse PractitionersNursesNursing ResearchNursing SchoolsOccupationsOperations ResearchOperative Surgical ProceduresOpportunistic InfectionsOrganismOther FindingOutcomeOutcome StudyOutpatientsPainPamphletsParkinson DiseaseParticipantPathologyPatient CarePatient RecruitmentsPatientsPatternPediatricsPeer ReviewPerformancePericardial effusionPersonal SatisfactionPersonsPharmaceutical PreparationsPharmacistsPharmacologic SubstancePharmacologyPharmacy SchoolsPharmacy facilityPhasePhotocopyingPhysical DialysisPhysician AssistantsPhysician ExecutivesPhysiciansPilot ProjectsPlayPliabilityPoliciesPolicy ResearchPopulationPositioning AttributePostdoctoral FellowPostpartum PeriodPredispositionPreparationPrevalencePrevalence StudyPreventionPrevention strategyPreventivePreventive MedicinePrimary Care PhysicianPrimary Health CarePrincipal InvestigatorPrivate PracticePrivate SectorProblem SolvingProcessProductionProductivityProfessional PracticeProspective StudiesProtease InhibitorProtein IsoformsProtocols documentationPsychologyPublic HealthPublic Health EducationPublic Health NursesPublic Health NursingPublic Health PracticePublic Health SchoolsPublic Health StudentsPublicationsPublished CommentPublishingPulmonary TuberculosisPurposeQualifyingRadiationRandomized Clinical TrialsRangeRateReactionReadingRecommendationRecordsRecruitment ActivityRecurrent diseaseReportingResearchResearch ActivityResearch DesignResearch InfrastructureResearch InstituteResearch MethodologyResearch Peer ReviewResearch PersonnelResearch Project GrantsResearch SupportResearch TrainingResidenciesResistanceResolutionResourcesRespiratory Tract InfectionsRestriction fragment length polymorphismReview CommitteeReview LiteratureRewardsRifampinRiskRisk FactorsRoleRotationRuralSECTM1 geneSafetySample SizeSaudi ArabiaScheduleSchool NursingSchoolsScienceScientistSeriesServicesSevere Acute Respiratory SyndromeSiteSite VisitSmallpoxSocietiesSodium ChlorideSourceSouth CarolinaSpecialistSputumStagingStatistical MethodsStructureStudentsSubgroupSupervisionSurrogate MarkersSurveysSusceptibility GeneSystemTanzaniaTechniquesTelefacsimileTelephoneTemperamentTest ResultTestingTexasThe science of MycologyTherapeutic AgentsThinkingTimeTissue BankingTrainingTraining ActivityTraining ProgramsTraining and EducationTranslational ResearchTransplantationTravelTreatment ProtocolsTrustTuberculosisTuberculosis VaccinesUncertaintyUnited StatesUnited States Department of Veterans AffairsUnited States Dept. of Health and Human ServicesUnited States Food and Drug AdministrationUnited States National Academy of SciencesUnited States National Institutes of HealthUnited States Public Health ServiceUniversitiesUniversity HospitalsUrsidae FamilyUtahVaccinatedVaccinesVancomycinVancomycin resistant enterococcusVertical Disease TransmissionVeteransViralViral Load resultVisionVisitVotingWashingtonWeekWithholding TreatmentWorkWritingZimbabweabstractingalcohol abuse therapyantiretroviral therapybasebiodefensebiomedical scientistcare seekingcareercase controlclinical research siteclinically relevantcollegecompare effectivenesscomputer designconceptcookingcostcost effectivenesscysteine rich proteindata managementdaydesigndisorder controldrug abusereffusionepidemiology studyexpectationexperiencefacsimilefallsfollow-upfollower of religion Jewishgene discoverygenetic analysisgenetic epidemiologyhealth administrationhealth economicshospice environmenthuman diseaseimprovedinterestintervention programisoniazidlecturesmacrophagemedical schoolsmembermenmicrobialmonocytemultidisciplinarymycobacterialnext generationnovel vaccinesoncologypatient orientedpatient oriented researchpeerplanetary Atmospherepreventprofessorprogramsprospectiveprotocol developmentquality assurancerepositoryresearch and developmentresearch in practiceresearch studyrespiratoryresponserifapentinerole modelschool healthskillssocialsubstance abusersuccesssymposiumsynergismteachertherapeutic vaccinetime usetransmission processtuberculosis treatmentvaccine developmentwardwillingness
National Institute of Allergy and Infectious Diseases
CFDA Code
855
DUNS Number
044387793
UEI
TP7EK8DZV6N5
Project Start Date
01-July-2004
Project End Date
31-March-2009
Budget Start Date
01-April-2007
Budget End Date
31-March-2008
Project Funding Information for 2007
Total Funding
$99,166
Direct Costs
$91,820
Indirect Costs
$7,346
Year
Funding IC
FY Total Cost by IC
2007
National Institute of Allergy and Infectious Diseases
$99,166
Year
Funding IC
FY Total Cost by IC
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