PROJECT SUMMARY The overarching mission of this project is to develop a Center entitled PRE-Clinical Interagency reSearch resourcE-Traumatic Brain Injury (PRECISE-TBI) with the mission of accelerating the development of therapies for TBI. PRECISE-TBI will achieve this mission by utilization of an enterprise approach to meet key objectives with targeted strategies. We will also leverage previous collaborative efforts. The organizational structure of PRECISE-TBI incorporates elements from business models and from other research consortia. The strategic missions of the Center are divided into five Cores and milestones will be achieved by activities of Core Directors and members. Leadership of PRECISE-TBI will be the Core Directors (Drs. Dixon, Gurkoff, VandeVord, Martone, LaPlaca, Harris, Floyd) and the Steering Committee Chair, Dr. Adam Ferguson. Leadership will interact with a Steering Committee (comprised of persons representing clinical expertise, other VA programs, other agencies, and all model types) to set objectives, milestones, and deliverables. We will have a Community Committee to be comprised of 100+ persons with wide TBI knowledge and perspectives. Committee members will be divided into task-oriented subcommittees, with oversight/guidance from Leadership and the Steering Committee. Core Directors, Steering Committee Chair, and the Steering Committee members are carefully selected to provide diversity and inclusion in TBI expertise, geographic location, funding history, gender identity, seniority, and research focus. Expertise in both acute and chronic TBI as well as pediatric TBI models will be included. Representatives from industry and non-profit organizations are included in the Steering Committee. The AO/Scientific Writer will compose drafts of documents for finalizing by Committee members. The organization structure of PRECISE-TBI connects investigators in both the Steering Committee and in the Community Committee which facilitates efficiency and wide-range engagement. Each of the Cores has an overarching objective that will be met by aims and milestones. The mission of the Administration Core is to promote effective and efficient communication and interactions between all elements of PRECISE-TBI. The working perspective is that the TBI investigators will act as both “employees” and “customers.” This dual role is because TBI investigators will be engaged to develop (employees) and use (customer) the consensus statements and translational roadmaps. The overarching goal of the Preclinical Model Catalogue Core is the creation, dissemination and maintenance of an online catalogue of preclinical models of TBI as well as create a database of preclinical TBI outcomes that are ontological to human TBI pathologies. The Common Data Elements Core mission is to develop and then benchmark new and existing common data elements using existing data from funded consortia and data from new endeavors. The Informatics Core seeks to fuel knowledge discovery through the development and implementation of a researcher-friendly infrastructure to support data sharing and implement standards and practices to make preclinical TBI data Findable, Accessible, Interoperable, and Reusable (FAIR). The mission of the Field TBI Program Coordination Core is to provide a bridge between the Center and the larger TBI community by leveraging existing infrastructure and growing the interactive community to use Center resources. Collectively, the Leadership, Steering Committee, Community Committee and Cores of PRECISE-TBI will support and accelerate the development of new candidate therapies for TBI.

PROJECT NARRATIVE The overarching mission of this project is to develop a Center entitled PRE-Clinical Interagency reSearch resourcE-Traumatic Brain Injury (PRECISE-TBI) with the mission of accelerating the development of therapies for TBI. PRECISE-TBI will achieve this mission by utilization of an enterprise approach to meet key objectives with targeted strategies and by leveraging previous collaborative efforts. The strategic missions of the Center are divided into five Cores and milestones will be achieved by activities of Core Directors and members. Leadership of PRECISE-TBI will be the Core Directors (Drs. C. Edward Dixon, Gene Gurkoff, Pamela VandeVord, Maryann Martone, Michelle LaPlaca, Neil Harris, Candace Floyd) and the Steering Committee Chair, Dr. Adam Ferguson. Leadership will interact with the Steering Committee and a Community Committee to set objectives, milestones, and deliverables.