Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP)
Project Number5RM1DA055311-03
Contact PI/Project LeaderMERLIN, JESSICA S Other PIs
Awardee OrganizationUNIVERSITY OF PITTSBURGH AT PITTSBURGH
Description
Abstract Text
PROJECT SUMMARY/ABSTRACT: The Tailored Retention and Engagement for Equitable Treatment of OUD
and Pain (TREETOP) clinical research center at the University of Pittsburgh (Pitt) is part of the NIH IMPOWR
network. TREETOP draws on the NIDA Clinical Trials Network Appalachian (Pennsylvania & West Virginia)
and Western States (Oregon) Nodes and the Community-based OUD and Pain Enhanced treatment (COPE)
collaborative (Baltimore, Maryland) to develop effective, equitable, and sustainable interventions for chronic
pain and OUD. Our overall goal is to improve treatment for comorbid chronic pain and OUD across the OUD
Treatment Cascade, prioritizing two disproportionately impacted communities for whom equitable
implementation of effective interventions can be challenging: rural and Black communities. We will achieve our
overall goal through the integrated contributions of 5 center components as follows: 1) Research Site
Overview, Management, and Operations - Our diverse multidisciplinary team has extensive experience with
multisite clinical trials as well as in TREETOP’s two emphasis areas, health equity and implementation
science. 2) Engagement and Outreach - Our TREETOP Stakeholder Consultation Board (SCB) includes
representatives with a variety of perspectives and lived experiences from each clinic and community partnering
in our studies and will serve as active participants on the research team. 3) Engagement/Retention Research
Projects - Both projects share the central premise that treating chronic pain improves pain and OUD
outcomes, tailor a pain self-management (PSM) intervention to patients with co-morbid chronic pain and OUD,
and evaluate both the intervention effectiveness and the barriers and facilitators to equitable and sustained
implementation of the intervention through the Health Equity Implementation Framework. Specifically, the
Engagement research project investigates whether PSM can improve pain and engage primary care patients
in medication treatment for OUD, while the Retention project investigates whether PSM and/or flexibly dosed
buprenorphine/naloxone can improve pain and retention in treatment among patients who have already
initiated care in office-based addiction treatment programs. 4) Data Collection, Management, and
Harmonization - The Data Core will be led by investigators with a track record of success in the measurement
and analysis of patient-reported outcomes and in leading clinical trials and data coordinating centers, and
includes national leaders in the PROMIS Health Organization. 5) Pilot Projects - Our Pilot program includes 3
initial studies on pain measurement, chronic pain/OUD treatment implementation in specialty settings, and
chronic pain and OUD stigma, and then follows a standard protocol for soliciting and reviewing future pilot
projects addressing health equity and implementation science. Overall Impact: Our TREETOP investigators
and SCB will collaborate to advance the science of sustainably and equitably managing chronic pain and OUD,
prioritizing disproportionately impacted rural and Black communities.
Public Health Relevance Statement
Project Narrative: We will create the Tailored Retention and Engagement for Equitable
Treatment of OUD and Pain (TREETOP) clinical research center, an IMPOWR clinical research
center at the University of Pittsburgh (Pitt) that develops effective, equitable, and sustainable
interventions for chronic pain and OUD that improve engagement in medication for OUD
treatment and retention in office-based addiction treatment. TREETOP will prioritize two
disproportionately impacted communities for whom equitable implementation of effective
interventions can be challenging: rural and Black communities. TREETOP’s success will not
only advance the science in this area but will advance the professional development of early-
career investigators and help grow our field long-term.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AddressAppalachian RegionAreaBaltimoreBlack raceCaringClinicClinical DataClinical ResearchClinical SciencesClinical TrialsClinical Trials NetworkCollaborationsCommunitiesConsultationsDataData CollectionData Coordinating CenterDecision MakingDevelopmentDoseEffectivenessEffectiveness of InterventionsEnsureEnvironmentEquityFundingFutureGoalsHospitalizationInfrastructureInterventionLeadershipLived experienceMarylandMeasurementMeasuresMedicalMentorsMulti-Institutional Clinical TrialNational Institute of Drug AbuseOregonOutcomePainPain ClinicsPain MeasurementParticipantPatient Outcomes AssessmentsPatientsPennsylvaniaPharmaceutical PreparationsPilot ProjectsPositioning AttributeProcessProductivityProtocols documentationRandomized, Controlled TrialsRecommendationReproducibilityResearchResearch PersonnelResearch Project GrantsRuralScienceSiteSuboxoneTestingTranslational ResearchUnited States National Institutes of HealthUniversitiesWest Virginiaaddictioncareerchronic painchronic pain managementchronic pain patientclinical centerclinical paincommunity partnerscomorbiditydata harmonizationeffective interventionexperienceflexibilityhealth equityhealth organizationimplementation frameworkimplementation interventionimplementation scienceimprovedinnovationmedical specialtiesmeetingsmembermultidisciplinarynew technologyoperationoutreachpain self-managementprimary care patientprogramsracial biassocial stigmasuccesstreatment program
National Institute of Neurological Disorders and Stroke
$1,240,311
Year
Funding IC
FY Total Cost by IC
Sub Projects
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Publications
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Outcomes
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Clinical Studies
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History
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