Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function
Project Number3R01NS110609-05S2
Former Number5R01NS110609-05
Contact PI/Project LeaderBONDI, CORINA OANA
Awardee OrganizationUNIVERSITY OF PITTSBURGH AT PITTSBURGH
Description
Abstract Text
The NINDS Landis Award for Outstanding Mentorship is an incredible and humbling opportunity to
supplement training-related activities ongoing through Dr. Corina Bondi’s R01 parent grant
(R01NS110609). The parent grant aims to assess cognitive- and anxiety-like dimensions sensitive to
both traumatic brain injury (TBI) and aging, as the elderly represent a high risk population for both
cognitive decline and TBI incidence, and to address mechanistic questions regarding altered cholinergic
neurotransmission responsible for such deficits by restoring neurobehavioral performance in young adult
and aged rats, males and females, by means of administration of NS-1738, positive allosteric modulator
of α7 nicotinic cholinergic receptors, alone or in combination with a daily environmental enrichment
paradigm. The Landis Award supplement will provide funds for a postdoctoral fellow (Dr. Bondi’s current
graduate student) for four months to complete data analyses and publications, a one year full-time
postbaccalaureate research technician and a summer student, to complete experiments proposed on the
parent grant. It will also provide supplies needed to complete experiments for both a senior diversity
undergraduate funded through a URM supplement on the parent R01 and a medical student helping Dr.
Bondi and her advanced resident fellow on a pilot project complementary to the parent award. Moreover,
funding will ensure that multiple (eight) trainees will attend national and international conferences to
present their work. They range from senior undergraduate and postbaccalaureate fellows, to medical
students and postdoctoral fellow to attend and present at five different conferences, such as the National
Neurotrauma Society, the Society for Neuroscience, the International Behavioral Neuroscience Society,
the Society for the Advancement of Chicanos and Native Americans in Science, as well as the
International Conference on Cognitive and Behavioral Neurosciences. Additionally, Dr. Bondi will invite
her new young faculty URM mentee from the University of Puerto Rico at Cayey, to present at the
National Neurotrauma Symposium, where Dr. Bondi was recently elected as Vice President. Finally,
additional funds will be ensure publication costs for five manuscripts with trainees/mentees as first and
middle co-authors, as well as purchasing a necessary portable computer in the lab for centralizing and
enhancing efficiency of presentation and publication construction by trainees.
Public Health Relevance Statement
Narrative
Dr. Corina Bondi is a tenured Associate Professor in the Departments of Physical Medicine and
Rehabilitation and Neurobiology, and a member of the training faculty in the Center for Neuroscience at
the University of Pittsburgh. Her R01 parent grant (R01NS110609) aims to assess cognitive- and
anxiety-like dimensions sensitive to both traumatic brain injury (TBI) and aging, as the elderly represent a
high risk population for both cognitive decline and TBI incidence, and to address mechanistic questions
regarding altered cholinergic neurotransmission responsible for such deficits. In 2024, Dr. Bondi was
awarded the NINDS Landis Award for Outstanding Mentorship to supplement training-related activities,
and it will be used to ensure the salaries of a postdoc for 4 months, a postbaccalaureate trainee for one
year, as well as for research supplies for the URM undergraduate supplementee on the R01 and a
medical student, travel for 8 mentees to conferences, publication costs for my trainees, and a portable
computer for training purposes (papers, talks, posters, etc).
NIH Spending Category
No NIH Spending Category available.
Project Terms
AddressAgingAnxietyAwardBehavioralCholinergic ReceptorsCognitiveComputersData AnalysesDimensionsElderlyEnsureFacultyFemaleFundingImpaired cognitionIncidenceInternationalManuscriptsMedical StudentsMentorshipMexican AmericansNational Institute of Neurological Disorders and StrokeNative AmericansNervous System TraumaNeurobiologyNeurosciencesPaperParentsPerformancePhysical MedicinePhysical RehabilitationPilot ProjectsPostbaccalaureatePostdoctoral FellowPublicationsPuerto RicoRattusResearchScienceSocietiesSystemTeacher Professional DevelopmentTrainingTraumatic Brain InjuryTravelUniversitiesWagesWorkagedcholinergiccostenvironmental enrichment for laboratory animalsexecutive functionexperimental studygraduate studenthigh risk populationmalemembermid-career facultyneurobehavioralneurotransmissionparent grantparent projectportabilitypositive allosteric modulatorposterssummer studentsustained attentionsymposiumundergraduate studentyoung adult
National Institute of Neurological Disorders and Stroke
CFDA Code
853
DUNS Number
004514360
UEI
MKAGLD59JRL1
Project Start Date
01-August-2024
Project End Date
30-April-2026
Budget Start Date
01-August-2024
Budget End Date
30-April-2026
Project Funding Information for 2024
Total Funding
$159,000
Direct Costs
$100,000
Indirect Costs
$59,000
Year
Funding IC
FY Total Cost by IC
2024
National Institute of Neurological Disorders and Stroke
$159,000
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 3R01NS110609-05S2
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 3R01NS110609-05S2
Patents
No Patents information available for 3R01NS110609-05S2
Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 3R01NS110609-05S2
Clinical Studies
No Clinical Studies information available for 3R01NS110609-05S2
News and More
Related News Releases
No news release information available for 3R01NS110609-05S2
History
No Historical information available for 3R01NS110609-05S2
Similar Projects
No Similar Projects information available for 3R01NS110609-05S2