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76 Projects
Fiscal Year: Active ProjectsAgency/Institute/Center: Nat'l Inst of General Medical Sciences (NIGMS)Admin: YesActivity Code: R21
TActProjectYearSubPrincipal Investigator(s)/ Project Leader(s)OrganizationFiscal YearAdmin ICFunding ICFY Total Cost by ICSimilar Projects
Electrokinetic lithography: in situ microengineering of anisotropic 3D collagen matrices
5TfR21ActfGM143658Projectf02YearfROCHESTER INSTITUTE OF TECHNOLOGY2023NIGMS
NIGMS
$185,000
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Development of tunable DNA-based material technology
5TfR21ActfGM146088Projectf02YearfUNIVERSITY OF FLORIDA2023NIGMS
NIGMS
$228,750
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Developing a redox-mediated single NP detection for bioconjugate analysis.
1TfR21ActfGM155760Projectf01YearfUNIVERSITY OF NEVADA RENO2024NIGMS
NIGMS
$206,028
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High-speed, real-time feedback-driven single particle tracking with concurrent smFRET
1TfR21ActfGM157695Projectf01YearfBOSTON UNIVERSITY (CHARLES RIVER CAMPUS)2025NIGMS
NIGMS
$193,339
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Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
5TfR21ActfGM149078Projectf02YearfUNIVERSITY OF SOUTHERN CALIFORNIA2024NIGMS
NIGMS
$195,490
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Polysome Shadowing
5TfR21ActfGM148845Projectf02YearfUNIVERSITY OF CALIFORNIA SANTA CRUZ2024NIGMS
NIGMS
$231,000
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Establishment of a multi-center biobank of patient-specific induced pluripotent stem cells for pediatric sepsis research
5TfR21ActfGM150093Projectf02YearfCINCINNATI CHILDRENS HOSP MED CTR2024NIGMS
NIGMS
$215,707
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Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping
5TfR21ActfGM151703Projectf02YearfCINCINNATI CHILDRENS HOSP MED CTR2024NIGMS
NIGMS
$217,536
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Prediction of nearest neighbor parameters for folding RNAs with modified nucleotides
5TfR21ActfGM148835Projectf02YearfUNIVERSITY OF CALIFORNIA AT DAVIS2024NIGMS
NIGMS
$164,971
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TRACTOR: A Computational Platform to Explore Matrix-Mediated Mechanical Communication among Cells
5TfR21ActfGM147898Projectf02YearfUNIVERSITY OF MINNESOTA2023NIGMS
NIGMS
$184,625
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Technology to Create Spiegel ERAbodies on Demand: Biostable Universal Antibody Replacements
5TfR21ActfGM147764Projectf02YearfFOUNDATION FOR APPLIED MOLECULAR EVOLUTN2023NIGMS
NIGMS
$193,125
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Development of remotely actuated deformable membranes for in situ mechanical testing of soft tissue
5TfR21ActfGM137275Projectf02YearfPURDUE UNIVERSITY2023NIGMS
NIGMS
$181,738
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Improving the Sensitivity and Selectivity of Laser Desorption Ionization Using N-Heterocyclic Carbene Mass Ionization Tags
1TfR21ActfGM155773Projectf01YearfUNIVERSITY OF NOTRE DAME2024NIGMS
NIGMS
$247,767
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An Integrated Catheter Dressing for Early Detection of Catheter-related Bloodstream Infections
5TfR21ActfGM150104Projectf02YearfTEXAS A&M UNIVERSITY2024NIGMS
NIGMS
$219,251
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Combining Absolute Quantitative Cross-Linking Mass Spectrometry and Molecular Modeling for Probing PROTAC-Mediated Ternary Complex Structures
5TfR21ActfGM148874Projectf02YearfNEW JERSEY INSTITUTE OF TECHNOLOGY2024NIGMS
NIGMS
$189,312
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Genetically Encoded Magnetometer for Intracellular Dynamic Measurement
1TfR21ActfGM154219Projectf01YearfJOHNS HOPKINS UNIVERSITY2024NIGMS
NIGMS
$235,586
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High-Throughput, Multiplexing-Ready Intracellular Pressure Probes
5TfR21ActfGM146105Projectf02YearfJOHNS HOPKINS UNIVERSITY2023NIGMS
NIGMS
$196,649
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Rational PROTAC design enabled by integrated in silico molecular modeling and in vitro biomimetic affinity assessment
5TfR21ActfGM151651Projectf02YearfUNIVERSITY OF CALIFORNIA RIVERSIDE2024NIGMS
NIGMS
$187,597
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Sequence Specific Inhibition of Protein Translation
5TfR21ActfGM141609Projectf02YearfUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2022NIGMS
NIGMS
$201,875
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Development of a nanobody tool kit to study connexin channels
1TfR21ActfGM155757Projectf01YearfUNIVERSITY OF CALIFORNIA AT DAVIS2024NIGMS
NIGMS
$201,250
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Development of a novel model to study the effects of LINE-1 retrotransposons in disease and normal physiology using nanobodies
1TfR21ActfGM155785Projectf01YearfMERCER UNIVERSITY MACON2024NIGMS
NIGMS
$176,238
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Photochemical Technologies for Improved Glycosylation Reactions
5TfR21ActfGM149588Projectf02YearfUNIVERSITY OF GEORGIA2024NIGMS
NIGMS
$179,694
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Electron Spin Resonance Microfluidics as a new tool in chemical single cell population analysis
5TfR21ActfGM143595Projectf02YearfWEST VIRGINIA UNIVERSITY2023NIGMS
NIGMS
$168,000
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A novel method to characterize cis-regulatory complexes during development
5TfR21ActfGM147755Projectf02YearfCITY COLLEGE OF NEW YORK2023NIGMS
NIGMS
$235,500
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Scalable and Interoperable framework for a clinically diverse and generalizable sepsis Biorepository using Electronic alerts for Recruitment driven by Artificial Intelligence (short title: SIBER-AI)
5TfR21ActfGM148931Projectf02YearfEMORY UNIVERSITY2024NIGMS
NIGMS
$184,487
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Development of size-selective capture and release membranes for purification of extracellular vesicles
5TfR21ActfGM146156Projectf02YearfROCHESTER INSTITUTE OF TECHNOLOGY2023NIGMS
NIGMS
$185,000
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Toward synthetic chemically defined mRNA for human therapeutics
5TfR21ActfGM150088Projectf02YearfWAKE FOREST UNIVERSITY HEALTH SCIENCES2024NIGMS
NIGMS
$230,891
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Development of large-scale sequence-function relationship using in situ optical sequencing
5TfR21ActfGM148901Projectf03YearfUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR2024NIGMS
NIGMS
$176,600
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Graphene covalent grids for single-particle cryo-EM
1TfR21ActfGM154202Projectf01YearfUNIVERSITY OF ARKANSAS AT FAYETTEVILLE2024NIGMS
NIGMS
$238,845
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Recombinase polymerase amplification to enable same-cell, DNA/RNA multi-omic single cell sequencing
5TfR21ActfGM152950Projectf02YearfSLOAN-KETTERING INST CAN RESEARCH2025NIGMS
NIGMS
$199,125
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Microscale Enzymatic Remodeling of Molecular Glycosylation
1TfR21ActfGM152878Projectf01YearfWEST VIRGINIA UNIVERSITY2024NIGMS
NIGMS
$228,000
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Novel geometric deep learning models for tissue structure-aware spatial expression representations from spatially resolved single-cell transcriptomics data
1TfR21ActfGM155774Projectf01YearfUNIVERSITY OF PITTSBURGH AT PITTSBURGH2024NIGMS
NIGMS
$198,750
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Purification of Circular RNA by Ultrafiltration
5TfR21ActfGM145980Projectf02YearfCLEMSON UNIVERSITY2023NIGMS
NIGMS
$179,097
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Pyridoxal Photoenzymes for Organic Synthesis
7TfR21ActfGM146043Projectf03YearfPRINCETON UNIVERSITY2023NIGMS
NIGMS
$202,500
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High-resolution flexible mobility analyzer for point-of-care diagnostics
5TfR21ActfGM144819Projectf02YearfBATTELLE PACIFIC NORTHWEST LABORATORIES2023NIGMS
NIGMS
$246,416
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Cell tracking in low-frame-rate video based on displacement prediction
5TfR21ActfGM150066Projectf02YearfCLEMSON UNIVERSITY2024NIGMS
NIGMS
$177,197
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Developing CRISPR repeats as a means of phylogenetically profiling metagenomic data
5TfR21ActfGM147759Projectf02YearfUNIV OF MARYLAND, COLLEGE PARK2023NIGMS
NIGMS
$111,581
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A Plug-and-Play Platform for Continuous Directed Evolution of Nonribosomal Peptide Synthetases
1TfR21ActfGM154190Projectf01YearfBAYLOR COLLEGE OF MEDICINE2024NIGMS
NIGMS
$240,000
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New Chemical Tools to Measure Cell Membrane Tension in Vivo
5TfR21ActfGM153048Projectf02YearfUNIVERSITY OF CALIFORNIA, SAN DIEGO2025NIGMS
NIGMS
$213,300
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Quantitative Single Cell Mass Spectrometry for Small Molecules with Unprecedented Sensitivity
5TfR21ActfGM146085Projectf02YearfUT-BATTELLE, LLC-OAK RIDGE NATIONAL LAB2023NIGMS
NIGMS
$228,441
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Nanoplasmonic Spatiotemporal Imaging of Single-Cell Protein Secretion and Intercellular Communication
5TfR21ActfGM151528Projectf02YearfNEW YORK UNIVERSITY2024NIGMS
NIGMS
$196,819
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Developing graphene grids to overcome air-water-interface issues
1TfR21ActfGM154216Projectf01YearfSCRIPPS RESEARCH INSTITUTE, THE2024NIGMS
NIGMS
$276,000
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DEVELOP GENOMEWIDE TECHNOLOGY TO PROFILE DNA ADP-RIBOSYLATION
1TfR21ActfGM154218Projectf01YearfJOHNS HOPKINS UNIVERSITY2024NIGMS
NIGMS
$204,688
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Expedite Enzymatic Assembly of Glycans via DNA (de)Hybridization-Enabled Catch-and-Release
5TfR21ActfGM150050Projectf02YearfGEORGIA STATE UNIVERSITY2024NIGMS
NIGMS
$195,000
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Development of two-dimensional (2D) acoustic force elastography microscopy for the non-contact measurement of elastic property of cell encapsulated scaffolds
1TfR21ActfGM154167Projectf01YearfUNIVERSITY OF SOUTHERN CALIFORNIA2024NIGMS
NIGMS
$246,368
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EnzyDock-based Multistate and Multiscale Tools for Covalent Drug Design
5TfR21ActfGM148895Projectf02YearfUNIVERSITY OF TEXAS ARLINGTON2024NIGMS
NIGMS
$162,009
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Development of aerosol fluorescence spectrometer for measuring multiple physicochemical properties of respiratory and drug particles in situ
1TfR21ActfGM155887Projectf01YearfAUBURN UNIVERSITY AT AUBURN2024NIGMS
NIGMS
$229,454
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Exploring the sepsis-delirium connection through glycoproteomics
5TfR21ActfGM147847Projectf02YearfNORTHWESTERN UNIVERSITY2023NIGMS
NIGMS
$199,235
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Ultra-stable, photon-efficient cryogenic super-resolution fluorescence imaging for visualizing vitrified biological samples with molecular-scale resolution
5TfR21ActfGM147769Projectf02YearfSLOAN-KETTERING INST CAN RESEARCH2023NIGMS
NIGMS
$221,250
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Controlled Protein Translocation in Nanopores for Sequencing Applications
5TfR21ActfGM148844Projectf02YearfELECTRONIC BIOSCIENCES, INC.2024NIGMS
NIGMS
$219,055
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