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Fluorescence Microscopy

Project Number1ZICES102485-15 NIDB ANNUAL REPORT

Contact PI/Project LeaderTUCKER, CHARLES

Awardee OrganizationNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

Description

Abstract Text

In meeting the goals and objectives of FMIC, the center continues to: -Service and maintain state-of-the-art equipment for unlimited access by intramural scientists. -Provide investigator training in the use and analysis of fluorescence and optical-based techniques. -Develop and optimize experimental protocols in collaboration with intramural scientists. -Maintain and develop state-of-the-art analysis tools and protocols in collaboration with investigators -Monitor and incorporate emerging fluorescence and optical technologies that will support the mission of NIEHS into FMIC. During this fiscal year, FMIC has collaborated and supported 46 Principle Investigators from 8 branches/laboratories within the NIEHS DIR. Some publications from this FY resulting from work in the center is listed in the bibliography below: Bibliography Chen SH, Han S, Hu CF, Zhou R, Gao Y, Tu D, Gao H, Feng J, Wang Y, Lu RB, Hong JS. Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration. Antioxidants (Basel). 2022;11(6). Epub 2022/06/25. doi: 10.3390/antiox11061202. PubMed PMID: 35740099; PMCID: PMC9220294. Dickson MJ, Oh Y, Gruzdev A, Li R, Balaguer N, Kelleher AM, Spencer TE, Wu SP, DeMayo FJ. Inserting Cre recombinase into the Prolactin 8a2 gene for decidua-specific recombination in mice. Genesis. 2022:e23473. Epub 2022/04/28. doi: 10.1002/dvg.23473. PubMed PMID: 35475540. Fang Y, Fan W, Xu X, Janoshazi AK, Fargo DC, Li X. SIRT1 regulates cardiomyocyte alignment during maturation. J Cell Sci. 2022. Epub 2022/03/10. doi: 10.1242/jcs.259076. PubMed PMID: 35260907. Horton JK, Janoshazi AK, Nadalutti CA, Zhao ML, Stefanick DF, Wilson SH. Monitoring DNA polymerase mitochondrial localization and dynamics. DNA Repair (Amst). 2022;116:103357. Epub 2022/06/20. doi: 10.1016/j.dnarep.2022.103357. PubMed PMID: 35717762. Li H, Bradbury JA, Edin ML, Graves JP, Gruzdev A, Cheng J, Hoopes SL, Miller-Degraff L, Fessler MB, Garantziotis S, Schurman SH, Zeldin DC. sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae. J Clin Invest. 2021. Epub 2021/10/01. doi: 10.1172/jci129679. PubMed PMID: 34591792. Li R, Wang X, Huang Z, Balaji J, Kim TH, Wang T, Zhou L, Deleon A, Cook ME, Marbrey MW, Wu SP, Jeong JW, Arora R, DeMayo FJ. The role of epithelial progesterone receptor isoforms in embryo implantation. iScience. 2021;24(12):103487. Epub 2021/12/23. doi: 10.1016/j.isci.2021.103487. PubMed PMID: 34934913; PMCID: PMC8661479. Liu J, Yu L, Castro L, Yan Y, Clayton NP, Bushel P, Flagler ND, Scappini E, Dixon D. Short-term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF-beta signaling. Faseb j. 2022;36(2):e22101. Epub 2022/01/16. doi: 10.1096/fj.202101262R. PubMed PMID: 35032343. Oyarzabal EA, Hsu LM, Das M, Chao TH, Zhou J, Song S, Zhang W, Smith KG, Sciolino NR, Evsyukova IY, Yuan H, Lee SH, Cui G, Jensen P, Shih YI. Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network. Sci Adv. 2022;8(17):eabm9898. Epub 2022/04/30. doi: 10.1126/sciadv.abm9898. PubMed PMID: 35486721. Rodriguez KF, Brown PR, Amato CM, Nicol B, Liu CF, Xu X, Yao HH. Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B. Nat Commun. 2022;13(1):4130. Epub 2022/07/16. doi: 10.1038/s41467-022-31486-y. PubMed PMID: 35840551; PMCID: PMC9287316. Yan Y, Shi M, Fannin R, Yu L, Liu J, Castro L, Dixon D. Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells-Insights from Time Lapse Analysis. Biomedicines. 2022;10(4). Epub 2022/04/24. doi: 10.3390/biomedicines10040917. PubMed PMID: 35453667; PMCID: PMC9031958. Zhou J, Li J, Papaneri AB, Kobzar NP, Cui G. Dopamine Neuron Challenge Test for early detection of Parkinson's disease. NPJ Parkinsons Dis. 2021;7(1):116. Epub 2021/12/18. doi: 10.1038/s41531-021-00261-z. PubMed PMID: 34916526.

Public Health Relevance Statement

Data not available.

NIH Spending Category

Neurosciences

Project Terms

AntioxidantsBibliographyCadmiumCardiac MyocytesCellsChronicCollaborationsDNA RepairDNA-Directed DNA PolymeraseDeciduaEarly DiagnosisEnsureEnterobacteria phage P1 Cre recombinaseEpithelialEquipmentFarGoFibrosisFluorescenceFluorescence MicroscopyGenesGenetic RecombinationGoalsHeterogeneityHumanKnowledgeLaboratoriesLungMAPK3 geneMaintenanceMissionMitochondriaMonitorMusNational Institute of Environmental Health SciencesNerve DegenerationOpticsParkinson DiseasePathway interactionsPhagocytosisProgesterone ReceptorsProlactinProtein IsoformsProtocols documentationPubMedPublicationsResearchResearch PersonnelRoleSIRT1 geneScientistServicesSignal TransductionSomatic CellStreptococcus pneumoniaeSystemTechniquesTechnologyTestingTestisTimeTrainingTransforming Growth Factor betaUterine FibroidsWorkactivin Bautocrinebasecookingdopaminergic neuronfetalimaging facilitiesinsightinvestigator traininglocus ceruleus structuremacrophagemeetingsmigrationnatural Blastocyst Implantationneuroinflammationparacrineskillstetrabromobisphenol Athree dimensional cell culturetool

Details

Contact PI/ Project Leader

Name

TUCKER, CHARLES

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

City

Country

UNITED STATES

Department Type

Unavailable

Organization Type

Unavailable

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

2022

Award Notice Date

Administering Institutes or Centers

National Institute of Environmental Health Sciences

CFDA Code

DUNS Number

UEI

Project Start Date

Project End Date

Budget Start Date

Budget End Date

Project Funding Information for 2022

Total Funding

$1,942,001

Direct Costs

Indirect Costs

Year	Funding IC	FY Total Cost by IC
2022	National Institute of Environmental Health Sciences	$1,942,001

NIH Categorical SpendingClick here for more information on NIH Categorical Spending

Funding IC	FY Total Cost by IC	NIH Spending Category
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES	$1,942,001	Neurosciences

Sub Projects

No Sub Projects information available for 1ZICES102485-15

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 1ZICES102485-15

Patents

No Patents information available for 1ZICES102485-15

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 1ZICES102485-15

Clinical Studies

No Clinical Studies information available for 1ZICES102485-15

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