Ovine Model and Vaginal Microbiome Support for HIV Non-vaccine Biomedical Prevention Product Development
Project Number272201600008I-P00006-27200005-1
Contact PI/Project LeaderSWARTZ, GLENN
Awardee OrganizationADVANCED BIOSCIENCE LABORATORIES, INC.
Description
Abstract Text
Comprehensive Resources for HIVMicrobicides and Biomedical Prevention: The development of highly effective HIV prevention strategies, including a preventive vaccine and other non-vaccine biomedical prevention (nBP) products, remains one of the highest priorities for the Division of AIDS (DAIDS) and the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH). With current global HIV infection estimates exceeding 33 million people, the development of safe, effective, and acceptable nBP products to prevent the sexual transmission of HIV could play a major role in the worldwide reduction of the estimated 5000 new HIV infections per day. As promising nBP products emerge (e.g., microbicides, pre-exposure prophylaxis (PrEP) agents, and Multipurpose Prevention Technologies (MPT’s), there is a critical need to rapidly and efficiently move these candidates into clinical testing. The scope of work encompasses preclinical activities that range from initial product discovery to those required to support clinical trials and/or product licensure. This project will utilize ovine and vaginal microbiome models to support the development of HIV nBPs.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AIDS preventionAcquired Immunodeficiency SyndromeClinical TrialsDevelopmentDevicesDrug KineticsEvaluationHIVHIV InfectionsInvestigational DrugsLicensureModelingNational Institute of Allergy and Infectious DiseasePathway interactionsPersonsPlayPreventionPrevention strategyPreventive vaccineResourcesRoleSafetyServicesSheepTechnologyUnited States Food and Drug AdministrationUnited States National Institutes of HealthWorkanti-HIVmicrobicidemicrobicidenovel therapeuticspre-clinicalpre-exposure prophylaxispreventproduct developmentresearch clinical testingsexual HIV transmissionsheep modelvaginal microbiome
National Institute of Allergy and Infectious Diseases
CFDA Code
DUNS Number
094888294
UEI
MK4QC9EKZXG8
Project Start Date
01-February-2018
Project End Date
31-January-2019
Budget Start Date
Budget End Date
Project Funding Information for 2024
Total Funding
$2,998
Direct Costs
Indirect Costs
Year
Funding IC
FY Total Cost by IC
2024
National Institute of Allergy and Infectious Diseases
$2,998
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 272201600008I-P00006-27200005-1
Publications
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No Publications available for 272201600008I-P00006-27200005-1
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Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 272201600008I-P00006-27200005-1
Clinical Studies
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