The UCSD U19 Administrative Core A will be responsible for the overall coordination, communication, and management of this U19 Program. Duties of this UCSD Administrative Core A will include a plan for administering the AADCRC Infrastructure and Opportunity Fund (IOF) as requested in the RFA. Administrative Core A will have a structure administered by the PI in consultation with the UCSD U19 executive committee to coordinate the optimal functioning of the UCSD U19 by organizing monthly U19 scientific meetings as well as monthly U19 administrative and budget meetings. The PI will be administratively assisted by a budget administrator and an administrative assistant. The coordination of the optimal functioning will include the management, allocation, and prioritization of fiscal and other resources including travel to the annual U19 meeting in DC. An External Advisory Board will contribute to the successful function of this UCSD U19.To ensure excellent communication between the Projects and Cores comprising the UCSD U19, Administrative Core A will notify U19 investigators of planned scientific and administrative meetings, IOF funding announcements, and assist in the establishment of new U19 collaborations. Administrative Core A will also organize zoom conference calls, and in person meetings, for co-investigators located outside UCSD and arrange for travel to the annual U19 meeting in DC. To ensure the successful management of the UCSD U19, Administrative Core A will evaluate the progress of each Project and Core based on their projected annual milestones, and establish an environment that encourages collaboration and the use of UCSD “Severe Asthma Core B” resources. In addition, Core A will provide mechanisms for conflict resolution, and a PI leadership succession plan if needed. If selected by NIAID to administer the IOF funds, the PI will establish an administrative structure to manage the IOF which will include disbursing and tracking IOF funds awarded to new investigators, collaborative grants, and travel awards under the direction of the Steering Committee. In addition, the PI, his budget administrator, and the UCSD contracts office will implement plans for interacting with the institutions that will receive IOF funds, including establishing consortium agreements, when applicable. The PI and his budget administrator will also establish procedures, formats, and timelines for reporting on the status of IOF projects and expenditures to the NIAID and the AADCRC Steering Committee.