OVERALL SUMMARY This is a proposal to renew an Alzheimer's- related Resource Centers for Minority Aging Research (AD-RCMAR) called the Columbia University Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD). The thematic focus of the CIRAD is biological, behavioral, sociocultural, and environmental mechanisms of ADRD inequalities, including risk and resilience factors, biomarkers, and caregiving. It is critical to identify pathways between structural and social systems of exposure and ADRD outcomes in order to design interventions to narrow disparities and reduce the population burden of cognitive impairment and dementia. Over the past 4.5 years, CIRAD has built an extensive network that includes Core Leaders, Scientists, mentors, and collaborators from the four schools of the Columbia University Irving Medical Center, the Columbia University Alzheimer's Disease Research Center (ADRC), the Columbia Butler Aging Center, the CTSA Community Engagement Core, and the New York State Psychiatric Institute. We have engaged Scientists and mentors from New York City based institutions such as the City University of New York and the State University of New York, NYU, Weill Cornell Medical Center, Montefiore Medical Center and Albert Einstein College of Medicine, as well as other institutions around the country. The CIRAD Core leadership team includes former RCMAR Scientists who are well known for community-engaged research on ADRD inequalities. The goal of CIRAD is to provide sustained mentoring and career development, support for pilot studies, training in health disparities, and interdisciplinary collaboration to CIRAD Scientists and to support and accelerate research on the mechanisms of ADRD disparities so that they can be narrowed or eliminated. We will achieve our goals through: Aim 1. To establish and support a Leadership and Administrative Core, Aim 2. To establish a Research Education Core that will support a program that engages and supports early-stage investigators from historically excluded backgrounds interested in an independent career in ADRD research, Aim 3. To provide analytic guidance and support via an Analysis Core, and Aim 4. To accelerate research on mechanisms of ADRD disparities.

PROJECT NARRATIVE The Columbia Center for Interdisciplinary Research on Alzheimer's Disease Disparities will provide a reparative mentoring and leadership program, ADRD equity research training, pilot funding, and interdisciplinary collaboration to early career investigators from backgrounds that have been historically excluded in ADRD research. Our goal is to accelerate innovative research on the mechanisms of inequalities in ADRD, including biological, behavioral, sociocultural, environmental risk and resilience factors, biomarkers, and caregiving.