PROJECT SUMMARY: Director’s Overview and Essential Characteristics Brian Druker, M.D., Center Director The Knight Cancer Institute (KCI) at Oregon Health & Science University (OHSU) in Portland, Oregon, is the only NCI-designated comprehensive cancer center in our catchment area, the state of Oregon. Our goal is to leverage our unique strengths into treatment, early detection, and prevention strategies to improve patient outcomes. The KCI has 191 members belonging to four scientific programs (Cancer Biology, Translational Oncology, Quantitative Oncology, and Cancer Prevention and Control) and using six Shared Resources. In the past reporting period, we developed and are implementing a comprehensive strategic plan which defines three focus areas for our center: Culture of Inclusion and Innovation, Precision Oncology, and Precision Early Detection. We have defined a comprehensive Diversity Action Plan to align with OHSU's efforts to be an anti- racist institution and drive our efforts to ensure a Culture of Inclusion and Innovation within the KCI. Using our strategic plan as a compass, we recruited 56 investigators, including 12 senior leaders. We completed the design and construction of three new buildings, which allowed for the consolidation of our research and clinical care. We restructured our administration and advisory committees to ensure our members' engagement in the effective implementation of the strategic plan. These efforts have led to substantial increases in CCSG metrics, including NCI funding, intra- and inter-programmatic interactions, collaborative grants, and investigator-initiated trials. Thus, our current 191 KCI members are supported by $61.6 million in extramural funding, $26.9 million from the NCI. In the current funding period, members published 2,265 cancer-focused, peer-reviewed publications, of which 26% were intra-programmatic, 20% inter-programmatic, and 63% externally collaborative. In 2019, the last full year before the pandemic, 556 patients were enrolled on interventional treatment trials, representing 11% of our 5,065 new analytic cases. We continue our leadership in precision oncology (implementing sophisticated clinical trials based on comprehensive tumor analytics) and in advancing understanding of tumor biology, the immune microenvironment, and immunotherapeutics. We have provided leadership in numerous collaborative NCI projects and were selected to lead a Biden Cancer Moonshot grant, Evaluation of Population Based Testing for HBOC and Lynch Syndromes. We have refined and improved screening guidelines for multiple cancers, contributed to exercise guidelines for cancer survivors, made substantial investments in Community Outreach and Engagement, and invested in the education and training of the next-generation cancer workforce. Together, these achievements have accelerated progress towards driving scientific discoveries in precision oncology and precision early detection through our culture of inclusion and innovation.

PROJECT NARRATIVE: Director’s Overview and Essential Characteristics Brian Druker, M.D., Center Director The OHSU Knight Cancer Institute has made numerous impactful contributions since its designation as one of the nation’s National Cancer Institute Cancer Centers in 1997. Accomplishments include establishing the paradigm of targeted cancer therapy, now referred to as precision medicine. Through the work supported by our Cancer Center Support Grant, we conduct cancer research that spans basic, clinical, and prevention and control and aims to improve outcomes for individuals in our catchment area and throughout the nation.